Thiolated chitosan nanoparticles enhance anti-inflammatory effects of intranasally delivered theophylline

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Thiolated chitosan nanoparticles enhance anti-inflammatory effects of intranasally delivered theophylline

BACKGROUND Chitosan, a polymer derived from chitin, has been used for nasal drug delivery because of its biocompatibility, biodegradability and bioadhesiveness. Theophylline is a drug that reduces the inflammatory effects of allergic asthma but is difficult to administer at an appropriate dosage without causing adverse side effects. It was hypothesized that adsorption of theophylline to chitosa...

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The present study was aimed to develop thiolated chitosan nanoparticles of Zolmitriptan for brain targeting in migraine via intranasal drug delivery. The thiolated chitosan was prepared using thiogycolic acid and chitosan in presence of catalyst and characterized using FTIR and DSC studies. Drug loaded nanoparticles were prepared by ionic gelation method using Sodium tripolyphosphate. The prepa...

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Anti-inflammatory effects of theophylline and selective phosphodiesterase inhibitors.

Theophylline has been used in the treatment of airway diseases, for more than 50 years with benefit thought to be derived from its ability to elicit bronchodilatation. Recent evidence has, however, suggested that theophylline possesses anti-inflammatory activity. The molecular mechanism of action remains unclear, although inhibition of the phosphodiesterase (PDE) enzyme, an enzyme which catalyz...

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ژورنال

عنوان ژورنال: Respiratory Research

سال: 2006

ISSN: 1465-993X

DOI: 10.1186/1465-9921-7-112